A 34-year-old Spanish woman with a lifelong history of seasonal rhinoc
onjunctivitis and honey intolerance (pyrosis and abdominal pain) devel
oped, 3 weeks after starting ingestion of bee pollen, astenia, anorexi
a, abdominal pain, diarrhoea, peripheral blood hypereosinophilia and e
levated serum total IgE levels, A duodenal biopsy showed eosinophilic
infiltration of the mucosal layer, Other causes of hypereosinophilia w
ere not found. Repeated parasitological stool studies, as well as a du
odenal aspirate showed negative results. Symptoms, hypereosinophilia a
nd elevated IgE levels resolved after bee pollen ingestion was stopped
. This is a typical case of eosinophilic gastroenteritis by ingestion
of bee pollen in a woman with intolerance to honey bee, because the pa
tient fulfilled the usual diagnostic criteria: gastrointestinal sympto
ms were present, eosinophilic infiltration of the digestive tract was
demonstrated by biopsy, no eosinophilic infiltration of other organs w
as found and the presence of parasites was excluded. Honey intolerance
and/or bee pollen administration should be considered as a cause of e
osinophilic gastroenteritis.