Nucleotides - Part LX - Synthesis and characterization of new 2 '-O-methylriboside 3 '-O-phosphoramidites useful for the solid-phase synthesis of 2 '-O-methyloligoribonucleotides

Authors
Cramer, H Pfleiderer, W
Citation
H. Cramer et W. Pfleiderer, Nucleotides - Part LX - Synthesis and characterization of new 2 '-O-methylriboside 3 '-O-phosphoramidites useful for the solid-phase synthesis of 2 '-O-methyloligoribonucleotides, HELV CHIM A, 82(4), 1999, pp. 614-632
Citations number
27
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
82
Issue
4
Year of publication
1999
Pages
614 - 632
Database
ISI
SICI code
0018-019X(1999)82:4<614:N-PL-S>2.0.ZU;2-E
Abstract
A series of new 2'-O-methylribonucleoside 3'-O-[2-(4-nitrophenyl)ethyl dial kylphosphoramidites] 27-31, 33-38, 40-44, and 45-50 were synthesized and th eir stability and rc activity compared in automated oligonucleotide synthes is with the standard 2'-O-methylribonucleoside 3'-O-(beta-cyanoethyl diisop ropylphosphoramidites) 32, 39, 45, and 51, respectively. The 2-(4-nitrophen yl)ethyl (npe) and 2-(3-nitrophenyl)ethoxycarbonyl (npeoc) groups were used for the protection of the base moieties.