DISTRIBUTION OF MESSENGER-RNAS FOR PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP), PACAP RECEPTOR, VASOACTIVE INTESTINAL POLYPEPTIDE (VIP), AND VIP RECEPTORS IN THE RAT SUPERIOR CERVICAL-GANGLION

Authors
NOGI H HASHIMOTO H HAGIHARA N SHIMADA S YAMAMOTO K MATSUDA T TOHYAMA M BABA A
Citation
H. Nogi et al., DISTRIBUTION OF MESSENGER-RNAS FOR PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP), PACAP RECEPTOR, VASOACTIVE INTESTINAL POLYPEPTIDE (VIP), AND VIP RECEPTORS IN THE RAT SUPERIOR CERVICAL-GANGLION, Neuroscience letters, 227(1), 1997, pp. 37-40
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
227
Issue
1
Year of publication
1997
Pages
37 - 40
Database
ISI
SICI code
0304-3940(1997)227:1<37:DOMFPA>2.0.ZU;2-U
Abstract
The distribution of mRNAs for pituitary adenylate cyclase-activating p olypeptide (PACAP), PACAP receptor (PACAP-R), vasoactive intestinal po lypeptide (VIP) and two subtypes of VLP receptors (VIP1-R and VIP2-R) was examined by in situ hybridization in the superior cervical ganglio n (SCG) of the adult rat. PACAP-R mRNA was expressed intensely in virt ually all principal neurons. PACAP mRNA was expressed in approximately half of the principal neurons, where the levels of expression vary ex tensively. Intense expression of VLP mRNA was observed only in a few p rincipal neurons. Neither VIP1-R mRNA nor VIP2-R mRNA was detected in SCG cells. These findings suggest that PACAP, but not VIP, may functio n as a paracrine or autocrine regulatory factor through PACAP-R in the principal neurons of the SCG. (C) 1997 Elsevier Science Ireland Ltd.