S. Culine et al., EVALUATION OF LONG-TERM RESULTS OF A MODIFIED VAB-6 CHEMOTHERAPY REGIMEN IN A COHORT OF GOOD-RISK METASTATIC NON SEMINOMATOUS GERM-CELL TUMORS, Bulletin du cancer, 84(4), 1997, pp. 368-372
From 1984 to 1988, we conducted at Institut Gustave-Roussy a phase II
trial with a modified VAB-6 (mVAB-6) chemotherapy regimen in 50 patien
ts with good prognosis metastatic nan seminomatous germ-cell tumors, i
ncluding 27 patients (54%) with retroperitoneal lymph nodes only. The
mVAB-6 combination consisted of vinblastine 4 mg/m(2)/day nt a, of act
inomycin D 1 mg/m(2)/day nt dl, of cyclophosphamide 600 mg/m(2)/day at
dl, of cisplatin 120 mg/m(2)/day at dl and of bleomycin 20 mg/day fro
m dl to d3. Four cycles of mVAB-6 were delivered every 4 weeks. A comp
lete response was observed in 46 patients (92%). The other 4 patients
achieved a partial response with normal serum tumor markers. Forty-two
patients (84%) remain continuously free of disease. Eight relapses su
bsequently occurred 3 to 60 months after the end of treatment. Overall
45 patients (90%) remain free of disease after a median follow-up of
8 years. The long-term clinical toxicity Ic,as minimal Three patients
developed secondary tumors: 2 contralateral non seminomatous germ-cell
tumors and 1 pancreatic adenocarcinoma. We conclude that the mVAB-6 r
egimen yielded excellent results and minimal long-term toxicity in thi
s group of patients with very good-risk metastatic tumors.