Synthesis of some heterocyclic phosphonates and their antibacterial and antifungal activities

Fifteen heterocyclic phosphonate derivatives and their starting compounds h ave been evaluated in vitro for antibacterial and antifungal activities aga inst standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus a ureus (ATCC 29213), Escherichia coil (ATCC 25922), Pseudomonas aeruginosa ( ATCC 27853) and yeast-like fungi; Candida albicans and Candida tropicalis. The compounds newly synthesised have been identified by H-1-NMR, FT-IR and micro analysis. Among the tested compounds 12, 13, 16, 17, 18, 22 and 23 ar e found effective to inhibit the growth of Candida albicans and Candida tro picalis at the MICs between 100-800 mu g/mL. The compounds tested here gene rally do not exhibit considerable antibacterial activity at the concentrati on studied (100-800 mu g/mL), except compound 18 which exhibits antibacteri al activity against gram-positive bacteria at the MIC of 400 mu g/mL.