Crystal and molecular structure of biatractylolide from the Chinese herb plant Atractylodes macrocephala

Authors
Huang, ZQ Lin, YC Liu, SX Chan, WL
Citation
Zq. Huang et al., Crystal and molecular structure of biatractylolide from the Chinese herb plant Atractylodes macrocephala, I J CHEM B, 38(1), 1999, pp. 106-108
Citations number
1
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
1
Year of publication
1999
Pages
106 - 108
Database
ISI
SICI code
0376-4699(199901)38:1<106:CAMSOB>2.0.ZU;2-D
Abstract
Biatractylolide, a unique bisesquiterpenoid has been obtained from the Chin ese herb plant Atractylodes macrocephala Koidz, [alpha](D)(20) +256(0) (c. 0.02,CHCl3). The single crystal belongs to space group PZ(1)Z(1)Z(1) with a = 10.972 Angstrom, b = 23.377 Angstrom, c = 9.840 Angstrom. The unit of ce ll contains four molecules. The structure has been solved by direct methods and refined by least-squares method. Final R factor has been found to be 0. 045. Prilimary assay of bioactivity shows that biatractylolide, as atractyl olide, has the activity of releasing guinea pig ileum.