Fluorination of 2-chloro-3-formylquinolines using microwaves

Authors
Kidwai, M Sapra, P Bhushan, KR
Citation
M. Kidwai et al., Fluorination of 2-chloro-3-formylquinolines using microwaves, I J CHEM B, 38(1), 1999, pp. 114-115
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
38
Issue
1
Year of publication
1999
Pages
114 - 115
Database
ISI
SICI code
0376-4699(199901)38:1<114:FO2UM>2.0.ZU;2-3
Abstract
Fluorination on 2-chloro-3-formylquinolines has been carried out in sulfola ne, acetonitrile and acetamide using potassium fluoride (KF) and tetramethy lammonium chloride (TMAC) under microwave irradiation as well as convention al heating. The reaction time has been brought down from hours to minutes w ith improved yields using microwave irradiation. The rate of fluorination o f 2-chloro-3-formylquinoline is more in acetamide followed by acetonitrile.