A murine model for the study of Chlamydia trachomatis genital infections during pregnancy

Authors
Pal, S Peterson, EM de la Maza, LM
Citation
S. Pal et al., A murine model for the study of Chlamydia trachomatis genital infections during pregnancy, INFEC IMMUN, 67(5), 1999, pp. 2607-2610
Citations number
24
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
5
Year of publication
1999
Pages
2607 - 2610
Database
ISI
SICI code
0019-9567(199905)67:5<2607:AMMFTS>2.0.ZU;2-0
Abstract
Pregnant BALB/c mice were inoculated intravaginally on day 5 of gestation w ith the Chlamydia trachomatis mouse pneumonitis biovar. Animals that receiv ed 10(5), 10(6), or 10(7) inclusion-forming units (IFU) of C. trachomatis d elivered prematurely on days 15 to 16 of gestation. A focal inflammatory in filtrate was observed in the wall of the uterus on the day 14 of gestation in animals inoculated with 105 IFU. In this group of mice, immunohistochemi cal analysis showed chlamydial inclusions in the endometrium and fetal memb ranes.