Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers

Authors
Kotake, S Schumacher, HR Arayssi, TK Gerard, HC Branigan, PJ Hudson, AP Yarboro, CH Klippel, JH Wilder, RL
Citation
S. Kotake et al., Gamma interferon and interleukin-10 gene expression in synovial tissues from patients with early stages of Chlamydia-associated arthritis and undifferentiated oligoarthritis and from healthy volunteers, INFEC IMMUN, 67(5), 1999, pp. 2682-2686
Citations number
23
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
5
Year of publication
1999
Pages
2682 - 2686
Database
ISI
SICI code
0019-9567(199905)67:5<2682:GIAIGE>2.0.ZU;2-8
Abstract
Genetically determined differences in interleukin-10 (IL-10) and gamma inte rferon (IFN-gamma) responses in mice correlate viith clearance of Chlamydia pneumonitis infection. We measured the synovial expression of IL-10 and IF N-gamma and additional cytokine genes in patients who had recent onset Chla mydia-associated arthritis (Chl-AA). IL-IO and IFN-gamma mRNA were relative ly abundant in recent-onset Chl-AA.