Effect of temporary hepatic venous occlusion on hepatic arterial embolization - An experimental study

Citation
K. Horio et al., Effect of temporary hepatic venous occlusion on hepatic arterial embolization - An experimental study, INV RADIOL, 34(5), 1999, pp. 341-347
Citations number
19
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
INVESTIGATIVE RADIOLOGY
ISSN journal
00209996 → ACNP
Volume
34
Issue
5
Year of publication
1999
Pages
341 - 347
Database
ISI
SICI code
0020-9996(199905)34:5<341:EOTHVO>2.0.ZU;2-J
Abstract
RATIONALE AND OBJECTIVES. The authors evaluated the effect of hepatic venou s occlusion on hepatic arterial embolization in rats, METHODS. A Lipiodol-Iopamidol mixture was injected into the proper hepatic artery in rats during clamping the right side of the hepatic venous conflue nce. The distribution of Lipiodol-Iopamidol mixture in the sinusoids was an alyzed by histological examination with en bloc silver impregnation. The ex tent of the distribution of Lipiodol-Iopamidol mixture was compared in sinu soids with hepatic venous occlusion and in sinusoids without hepatic venous occlusion, RESULTS. Lipiodol-Iopamidol mixture was more widely distributed in the lobu les with hepatic venous occlusion than in the lobules without occlusion, CONCLUSIONS. Hepatic venous occlusion may enhance the effect of hepatic art erial embolization using Lipiodol emulsions and could be useful in the trea tment of hepatocellular carcinoma.