Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant

Authors
Doglio, A Laffont, C Caroli-Bosc, FX Rochet, P Lefebvre, JC
Citation
A. Doglio et al., Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant, J CLIN MICR, 37(5), 1999, pp. 1567-1569
Citations number
11
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
00951137 → ACNP
Volume
37
Issue
5
Year of publication
1999
Pages
1567 - 1569
Database
ISI
SICI code
0095-1137(199905)37:5<1567:SGOTAC>2.0.ZU;2-F
Abstract
The first and second generations of the Cobas Amplicor HCV assay were compa red among patients at risk of hepatitis C virus (HCV) infection. The second -generation test was found to be of greater sensitivity and of good specifi city among clinical specimens containing HCV RNA of different genotypes. Fi nally, this new test is shown to predict the outcome of interferon therapy better.