Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells
Ll. Carter et Km. Murphy, Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells, J EXP MED, 189(8), 1999, pp. 1355-1360
CD4(+) and CD8(+) T cells exhibit important differences in their major effe
ctor functions. CD8(+) T cells provide protection against pathogens through
cytolytic activity, whereas CD4(+) T cells exert important regulatory acti
vity through production of cytokines. However, both lineages can produce in
terferon (IFN)-gamma, which can contribute to protective immunity. Here we
show that CD4(+) and CD8(+) T cells differ in their regulation of IFN-gamma
production. Both lineages require signal transducer and activator of trans
cription (Stat)4 activation for IFN-gamma induced by interleukin (IL)-12/IL
-18 signaling, but only CD4(+) T cells require Stat4 for IFN-gamma inductio
n via the TCR pathway. In response to antigen, CD8(+) T cells can produce I
FN-gamma independently of IL-12, whereas CD4(+) T cells require IL-12 and S
tat4 activation. Thus, there is a lineage-specific requirement for Statil a
ctivation in antigen-induced IFN-gamma production based on differences in T
CR signaling between CD4(+) and CD8(+) T cells.