Molecular mechanisms of tumor metastasis and angiogenesis

Introduction: During the past decade, the molecular mechanisms in the proce ss of tumor metastases and angiogenesis have become better understood. Disc ussion: The development of metastases requires complex molecular interactio ns in the detachment of tumor cells from solid tumors, the degradation of t he extracellular matrix, escape from apoptosis, locomotion in the extracell ular matrix, immunologic escape in the circulation, adhesion to endothelial cells, and extravasation from the circulation at the target site of metast asis and induction of angiogenesis Conclusion: The increasing knowledge of these complex mechanisms offers new therapeutic approaches in the treatment of malignant diseases. This article will give an overview of the molecular mechanisms involved in the development of metastases and angiogenesis, and their clinical implications.