Quantitative abdominal aortic flow measurements at controlled levels of ergometer exercise

Measuring the exercise-induced flow changes in the arteries of the body is a major challenge, The use of quantitative MR flow measurements for this pu rpose is hampered by movement artifacts and ECG triggering problems, To qua ntify exercise-induced flow changes in the abdominal aorta, we applied a fa st hybrid phase contrast sequence with K-space segmentation and echo planar imaging readouts during a 12 heart beat, single breathhold post exercise s canning window after ergometer exercise in nine volunteers, Central k-space was acquired first. The changes in heart rate throughout the scanning wind ow were quantified. The mean decrease in heart rate after six heart beats p ost exercise was less than 4% and less than 14% after 11 heart beats indica ting that the exercise state was very well represented during the acquisiti on of central k-space, Abdominal aortic flow increased from 1.4 +/- 0.3 l/m in at rest to 7.9 +/- 1.1 l/min at 131 watt, Retrograde flow reached a maxi mum value of 1.2 l/min at rest, and lasted 140 ms on average, Only for one out of the nine volunteers was there any retrograde flow present during exe rcise (at 33 watt and 65 watt exercise). It was concluded that retrograde f low patterns in the abdominal aorta associated with oscillating wall shear stresses and development of atherosclerosis disappeared with increasing lev els of exercise, The feasibility of using fast quantitative phase contrast measurements during a post exercise scanning window to represent controlled exercise levels was demonstrated, (C) 1999 Elsevier Science Inc.