Assessment of iron oxide particles (AMI 227) and a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) in a tumor model implanted in rats

Authors
Loubeyre, P De Jaegere, T Miao, Y Landuyt, W Marchal, G
Citation
P. Loubeyre et al., Assessment of iron oxide particles (AMI 227) and a gadolinium complex (Gd-DOTA) in dynamic susceptibility contrast MR imagings (FLASH and EPI) in a tumor model implanted in rats, MAGN RES IM, 17(4), 1999, pp. 627-631
Citations number
12
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
MAGNETIC RESONANCE IMAGING
ISSN journal
0730725X → ACNP
Volume
17
Issue
4
Year of publication
1999
Pages
627 - 631
Database
ISI
SICI code
0730-725X(199905)17:4<627:AOIOP(>2.0.ZU;2-Y
Abstract
The objective of our study was to assess the feasibility of dynamic suscept ibility contrast MR technique after bolus injection of SPIO and Gd-DOTA in a tumor model implanted in rats. Tumors were subcutaneously implanted in 24 rats, A FLASH sequence and EPI were evaluated, Different doses of AMI 227 and Gd-DOTA were assessed, Mean signal intensity vs. time curves were plott ed. Well-shaped curves of the first pass of the contrast agent were only ob tained with Gd-DOTA, According to these results it appears difficult to ass ess tumor blood volume with USPIO dynamic susceptibility contrast imaging. (C) 1999 Elsevier Science Inc.