Sexual ambiguity: clinical and cytogenetic evaluation of 105 cases

We have studied 105 subjects with sexual ambiguity who attended the Institu te of Genetics, Osmania University, Hyderabad, India. They were investigate d for chromosomal constitutions and clinical profiles. The correlative resu lts significantly contributed to the classification of these subjects into male pseudohermaphroditism (60.95%), female pseudohermaphroditism (20.95%), true hermaphroditism (13.33%) and mixed gonadal dysgenesis (4.77%). The re sults also confirm the significant contribution of chromosome abnormalities (18.09%) and hormonal imbalances in the genesis of abnormal sexual develop ment. A thorough understanding of genetic, endocrinological and molecular m echanisms is necessary in the management of children with sexual ambiguity. Med Sci Res 27:205-207 (C) 1999 Lippincott Williams & Wilkins.