Polymorphism of the angiotensinogen gene and genetic predisposition to diabetic nephropathy in diabetes mellitus type 1

Authors
Chistyakov, DA Turakulov, RI Kondrat'ev, YY Shestakova, MV Nosikov, VV Dedov, II Debabov, VG
Citation
Da. Chistyakov et al., Polymorphism of the angiotensinogen gene and genetic predisposition to diabetic nephropathy in diabetes mellitus type 1, MOL BIOL, 33(2), 1999, pp. 177-179
Citations number
16
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
33
Issue
2
Year of publication
1999
Pages
177 - 179
Database
ISI
SICI code
0026-8933(199903/04)33:2<177:POTAGA>2.0.ZU;2-Y
Abstract
The T174M polymorphism (threonine (T) or methionine (M) in position 174 of the amino acid sequence) of the angiotensinogen (AGT) gene was studied in p atients with diabetes mellitus type 1 complicated with diabetic nephropathy (DN) (n = 26) or not complicated (n = 42). As compared with controls, the frequency of allele T in patients with DN was significantly lower (69.2% vs . 83.3%) and that of allele M was higher (30.8% vs. 16.7%). An association between the AGT gene polymorphism and DN in diabetes mellitus type 1 was su ggested for the Moscow population.