A DLST genotype associated with reduced risk for Alzheimer's disease

Authors
Sheu, KFR Brown, AM Kristal, BS Kalaria, RN Lilius, L Lannfelt, L Blass, JP
Citation
Kfr. Sheu et al., A DLST genotype associated with reduced risk for Alzheimer's disease, NEUROLOGY, 52(7), 1999, pp. 1505-1507
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
52
Issue
7
Year of publication
1999
Pages
1505 - 1507
Database
ISI
SICI code
0028-3878(19990422)52:7<1505:ADGAWR>2.0.ZU;2-B
Abstract
Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial ol-ketoglutarate dehydr ogenase complex, which is deficient in AD. The authors report that in 247 U S white subjects, homozygosity for DLST A19,117, T19,183 was associated wit h a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced ris k was marked in subjects who did not carry the apolipoprotein (APOE)-4 alle le (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.