Noradrenaline-degrading activity of monoamine oxidase is localized in noradrenergic neurons of the locus coeruleus of the rat

Authors
Hasegawa, Y Hida, T Arai, R
Citation
Y. Hasegawa et al., Noradrenaline-degrading activity of monoamine oxidase is localized in noradrenergic neurons of the locus coeruleus of the rat, NEUROSCI L, 264(1-3), 1999, pp. 61-64
Citations number
20
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
03043940 → ACNP
Volume
264
Issue
1-3
Year of publication
1999
Pages
61 - 64
Database
ISI
SICI code
0304-3940(19990402)264:1-3<61:NAOMOI>2.0.ZU;2-N
Abstract
We found intense monoamine oxidase (MAO) activity in rat locus coeruleus (L C) neurons by means of a histochemical method using noradrenaline as a subs trate. This MAO activity was abolished by clorgyline, a specific inhibitor of MAO type A. Fluorescence immunohistochemistry for tyrosine hydroxylase ( TH) combined with MAO histochemistry revealed intense MAO activity in virtu ally all TH-immunoreactive LC neurons (i.e. noradrenergic neurons). The res ults indicate that noradrenaline produced in LC neurons might be degraded b y MAO type A activity. (C) 1999 Elsevier Science Ireland Ltd. All rights re served.