Vallecular cyst is a rare cause of stridor and respiratory distress in infa
ncy and has been associated with sudden airway obstruction resulting in dea
th. In a retrospective review of eight cases over a 20-year period all infa
nts developed symptoms during the first week of life. All had strider and f
eeding difficulties and two required endotracheal intubation. Other common
findings included signs of increased work of breathing and episodes of cyan
osis. Failure to thrive was present in five patients diagnosed later than t
he first week of life. An abnormal or a hoarse cry was present in only two
patients. Diagnosis in all cases was made by endoscopy. Where a VC is clini
cally suspected, it is important to stress the need to visualize the base o
f the tongue during any diagnostic endoscopic procedure. At endoscopy, a sm
ooth localized mass arising from and distorting the lingual surface of the
epiglottis was identified. Histologically, the cysts contained respiratory
epithelium with mucous glands with an external lining of squamous epitheliu
m. Treatment by cyst marsupialization is safe and definitive, in particular
when performed by CO2 laser. (C) 1999 Wiley-Liss, Inc.