Synthesis, conformational studies and anthelmintic activity of a constrained PF1022A analogue

Authors
Scherkenbeck, J Dyker, H Gondol, D Harder, A Plant, A Reichel, F
Citation
J. Scherkenbeck et al., Synthesis, conformational studies and anthelmintic activity of a constrained PF1022A analogue, PEST SCI, 55(4), 1999, pp. 457-461
Citations number
25
Categorie Soggetti
Entomology/Pest Control
Journal title
PESTICIDE SCIENCE
ISSN journal
0031613X → ACNP
Volume
55
Issue
4
Year of publication
1999
Pages
457 - 461
Database
ISI
SICI code
0031-613X(199904)55:4<457:SCSAAA>2.0.ZU;2-6
Abstract
A mono-proline analogue of the potent anthelmintic cyclooctadepsipeptide PF 1022A has been synthesized. NMR studies in combination with molecular dynam ics simulations demonstrate that the confirmation of this analogue is both rigidified and distorted compared with the asymmetric conformation of PF102 2A. The backbone conformation is significant with respect to anthelmintic a ctivity. (C) 1999 Society of Chemical Industry.