LONG-TIME EFFICACY OF CYCLANDELATE AND PR OPRANOLOL IN PROPHYLAXIS OFMIGRAINE FOLLOWING 4 MONTHS OF TREATMENT

After a 4 months randomized double-blind study with cyclandelate versu s propranolol ail patients kept a miniaturized headache diary for one more year. Both duration of migraine attacks in hours and the number o f additional analgetic medication were recorded monthly. Reduction of the duration of migraine attacks in the clinical responders of the cyc landelate treated patients remained nearly unchanged. In the propranol ol responders the duration of migraine attacks in hours increased from the third month after finishing the medication and reached values com parable to those at the beginning of the active treatment. Intake of a dditional analgetic medication during the 1-year-follow-up was tower i n the cyclandelate responders than in the propranolol-responders. Cycl andelate can be described as an effective long-lasting drug in migrain e prophylaxis.