Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells

Authors
Saeki, K Shoji, Y Noro, T Miyase, T Nakamura, Y Funayama, M Isemura, M
Citation
K. Saeki et al., Inhibitory effects of tetragalloylglucose and digalloylhamamelose on adhesion and in vitro invasion of mouse lung carcinoma cells, PLANTA MED, 65(3), 1999, pp. 227-229
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
65
Issue
3
Year of publication
1999
Pages
227 - 229
Database
ISI
SICI code
0032-0943(199904)65:3<227:IEOTAD>2.0.ZU;2-S
Abstract
Tetragalloylglucose (TgG) and digalloylhamamelose (DgH) were found to inhib it adhesion to and invasion through Matrigel of mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. TgG inhibited matrix metallopro teinases (MMPs) from the tumor cells like (-)-epigallocatechin gallate, whe reas DgH did not. These results suggest that TgG and DgH inhibit tumor cell invasion by inhibiting MMPs and/or cell adhesion of the tumor cells.