Anti-apoptotic actions of cytokines in mammalian cells

Citation
Bj. Desai et He. Gruber, Anti-apoptotic actions of cytokines in mammalian cells, P SOC EXP M, 221(1), 1999, pp. 1-13
Citations number
161
Categorie Soggetti
Medical Research General Topics
Journal title
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE
ISSN journal
00379727 → ACNP
Volume
221
Issue
1
Year of publication
1999
Pages
1 - 13
Database
ISI
SICI code
0037-9727(199905)221:1<1:AAOCIM>2.0.ZU;2-9
Abstract
Apoptosis is now widely recognized as an important mode of cell death. Sinc e the apoptotic pathway is an active process, modulation of apoptosis is im portant in our understanding of cell pathophysiology. Recent data have show n the inhibition of apoptosis in different cell types exposed to certain cy tokines, Therapeutics that modulate the regulation of apoptosis provide an opportunity for the treatment of certain diseases. There are many reviews f or apoptosis induction and the regulators involved. The present report sele cts important articles on the recent data showing the anti-apoptotic abilit y of cytokines in mammalian cells, Other novel compounds showing anti-apopt otic functions are also reviewed.