The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

Authors
Cardona, PJ Cooper, A Luquin, M Ariza, A Filipo, F Orme, IM Ausina, V
Citation
Pj. Cardona et al., The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity, SC J IMMUN, 49(4), 1999, pp. 362-366
Citations number
9
Categorie Soggetti
Immunology
Journal title
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
ISSN journal
03009475 → ACNP
Volume
49
Issue
4
Year of publication
1999
Pages
362 - 366
Database
ISI
SICI code
0300-9475(199904)49:4<362:TIMOMT>2.0.ZU;2-X
Abstract
The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large g ranulomatous structures and eventual tissue damage.