Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 tothe distal end of the short arm of human chromosome 1

Four-and-a-half LIM domain proteins (FHL) possess four tandem repeats of LI M domain and an extra zinc finger. FHL family LIM proteins are unique when compared with other LIM-only proteins because they possess an odd number of zinc fingers. In this study, the tissue distribution and chromosomal mappi ng of skeletal muscle LIM protein FHL3 were reported When the FHL3 cDNA pro be was used to hybridize with poly-(A) RNA of various human tissues, a very strong signal was detected in skeletal muscle, and virtually no signal cou ld be detected in heart, brain, placenta, lung, liver kidney and pancreas. Using radiation hybrid technique, FHL3 gene was mapped to the distal end of the short arm of chromosome 1 (123.26 cR from the top of the Chr1 linkage group) and this region (near 1p34) is related to several human malignancies .