A new decoration for nitric oxide synthase - a Zn(Cys)(4) site

Authors
Ludwig, ML Marletta, MA
Citation
Ml. Ludwig et Ma. Marletta, A new decoration for nitric oxide synthase - a Zn(Cys)(4) site, STRUCT F D, 7(4), 1999, pp. R73-R79
Citations number
34
Categorie Soggetti
Biochemistry & Biophysics
Journal title
STRUCTURE WITH FOLDING & DESIGN
ISSN journal
09692126 → ACNP
Volume
7
Issue
4
Year of publication
1999
Pages
R73 - R79
Database
ISI
SICI code
0969-2126(19990415)7:4<R73:ANDFNO>2.0.ZU;2-M
Abstract
Intense interest in the action and synthesis of nitric oxide has fuelled st ructural studies of nitric oxide synthase (NOS). The monomeric and dimeric heme domains of inducible NOS were the first NOS structures to be described . A recent independent analysis of the corresponding heme domains from endo thelial NOS confirms most of the features found earlier and also reveals a novel Zn(Cys)(4) center - a new feature far NOS.