Heterocyclic synthesis with nitriles: Synthesis of some new chromone and flavone and its utilization for the synthesis of potentially antitumorigenicpolycyclic chromones and flavones.
Hm. Refat, Heterocyclic synthesis with nitriles: Synthesis of some new chromone and flavone and its utilization for the synthesis of potentially antitumorigenicpolycyclic chromones and flavones., SYN COMMUN, 29(9), 1999, pp. 1429-1436
A new synthesis of chromones and flavones based on the reaction of 2-hydrox
y-1-acetonaphthone (1) with cinammonitriles (2 a-h) is described. Structure
s of the compounds are established by chemical and spectral data. This synt
hetic approach appears general in its applicability. It has been applied to
the synthesis of a series of polycyclic chromone and flavone compounds con
taining the naphthalene and pyrene ring systems that hold promise as agents
for the chemo preventation of cancer.