Objectives. To compare the ability of different biopsy schemes to detect ca
ncer and predict tumor volume using our previously described prostate biops
y simulation system. In addition, we used the simulation system to evaluate
the optimal location of transition zone biopsies.
Methods. Digital reconstructions of 180 radical prostatectomy specimens wer
e used. Forty simulations were performed on each prostate for 10 biopsy sch
emes, including a previously reported five-region peripheral zone biopsy pa
ttern and a new 11-core multisite-directed scheme consisting of sextant, tw
o transition zone, one midline, and two anterior horn biopsies. For simulat
ion of the transition zone biopsies, paired near-midline biopsies were simu
lated, with needle insertion points from the apex to the base of the prosta
te and with needle advances of 1 to 4 cm before firing. A total of 1,180,80
0 individual biopsy tracks were simulated.
Results, The 11-core multisite-directed biopsy scheme had the highest detec
tion rate for cancers greater than 0.5 cc. This scheme reliably detected ca
ncer in 94% (138 of 147) of the cases. These results were significantly bet
ter than those of the sextant biopsy scheme (P <0.001) and the five-region
18-core peripheral zone scheme (P = 0.03). Compared with other schemes, the
re were increases in small-volume (0.5 cc or less) cancer detection by both
the 11-core multisite-directed and five-region schemes, but they were not
statistically significant. The multisite and the sextant plus four transiti
on zone biopsy schemes had the best correlation of mean total core cancer l
ength with total cancer volume. In the simulation of the transition zone bi
opsies, the highest detection rate was observed when the biopsies were init
iated at the most apical section and inserted for a depth of 3 cm before fi
ring.
Conclusions. Our simulation results suggest that the detection rate of pros
tate biopsies is not related solely to the number of cores taken. Core plac
ement (the regions of the prostate from which samples are taken) is also im
portant. The 11-core multisite-directed biopsy scheme performed the best, w
ith improved cancer detection rates and tumor volume correlation over other
schemes. On the basis of our simulations, this scheme has been chosen for
clinical evaluation. UROLOGY 53: 951-960, 1999. (C) 1999, Elsevier Science
Inc, All rights reserved.