(+)-cis-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine 1-oxide

Authors
Kumaradhas, P Kalyanam, N Ravikumar, K Mohan, KC Sridhar, MA Prasad, JS Nirmala, KA
Citation
P. Kumaradhas et al., (+)-cis-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine 1-oxide, ACT CRYST C, 55, 1999, pp. 614-615
Citations number
12
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
55
Year of publication
1999
Part
4
Pages
614 - 615
Database
ISI
SICI code
0108-2701(19990415)55:<614:(>2.0.ZU;2-S
Abstract
The title compound, C16H15NO4S, is a diltiazem drug intermediate. Diltiazem is an enantiomerically pure drug with calcium antagonist activity. The mol ecular packing is stabilized by hydrogen bonding. The amide and hydroxide g roups form hydrogen bonds with neighbouring molecules. The seven-membered r ing is in a twist-boat conformation. The methoxyphenyl group deviates sligh tly from planarity but the benzene ring is planar.