NEUROCHEMICAL ACTIONS OF VIGABATRIN AND TIAGABINE ALONE AND IN COMBINATION IN MOUSE CORTEX

1. The effects of repeated administration of the anticonvulsant compou nds, vigabatrin (VGB) and tiagabine (TGB), on gamma-aminobutyric acid (GABA) concentration and the activities of GABA-transaminase (GABA-T) and glutamic acid decarboxylase (GAD) were investigated in mouse corte x. 2. VGB alone increased GABA levels and decreased GABA-T and GAD act ivities. 3. TGB alone was essentially without effect. 4. Low doses of VGB and TGB in combination increased GABA levels when neither drug had such an effect alone. 5. Despite this observation, this study failed to establish any conclusive evidence for an interaction between VGB an d TGB that might help to explain their reported clinical synergism. (C ) 1997 Elsevier Science Inc.