THE MECHANISM OF THE RELAXING EFFECT OF ASCORBIC-ACID IN GUINEA-PIG ISOLATED TRACHEAL MUSCLE

Authors
Citation
E. Sipahi et Zs. Ercan, THE MECHANISM OF THE RELAXING EFFECT OF ASCORBIC-ACID IN GUINEA-PIG ISOLATED TRACHEAL MUSCLE, General pharmacology, 28(5), 1997, pp. 757-760
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
ISSN journal
03063623
Volume
28
Issue
5
Year of publication
1997
Pages
757 - 760
Database
ISI
SICI code
0306-3623(1997)28:5<757:TMOTRE>2.0.ZU;2-3
Abstract
1. The effect of ascorbic acid was studied in the guinea pig isolated tracheal muscle. 2. Ascorbic acid with relatively higher concentration s produced a dose-dependent relaxation in tracheal muscle submaximally precontracted with KCl, histamine, and carbachol. 3. Removing the epi thelium did not significantly alter the relaxing effect of ascorbic ac id in histamine- and KCl-precontracted strips. 4. The relaxing effect of ascorbic acid is stronger in carbachol-precontracted epithelium-den uded strips than in epithelium-intact strips. 5. Indomethacin, but not L-NAME, partially inhibited the relaxing effect of ascorbic acid. 6. These results indicate that the relaxation induced by ascorbic acid in guinea pig isolated tracheal muscle does not fully depend on the pres ence of epithelium but is partially mediated by the production of pros tanoids from smooth muscle. (C) 1997 Elsevier Science Inc.