EFFECT OF THE SULFONYLUREA GLYBURIDE ON SUPEROXIDE-DISMUTASE IN STREPTOZOTOCIN-INDUCED DIABETIC RAT MUSCLE

Authors
ALTAN N YIGIT S ELMALI E MALHATUN E ROTA S KILIC N
Citation
N. Altan et al., EFFECT OF THE SULFONYLUREA GLYBURIDE ON SUPEROXIDE-DISMUTASE IN STREPTOZOTOCIN-INDUCED DIABETIC RAT MUSCLE, General pharmacology, 28(5), 1997, pp. 795-796
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
28
Issue
5
Year of publication
1997
Pages
795 - 796
Database
ISI
SICI code
0306-3623(1997)28:5<795:EOTSGO>2.0.ZU;2-I
Abstract
1. The effect of glyburide (glibenclamide) treatment on the muscle sup eroxide dismutase (SOD) activity of diabetic rats has been studied. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased mu scle SOD activity and decreased blood glucose levels. 3. The results o f this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulinlike effects on muscle SOD activity in vivo. (C) 1997 Elsevier Science Inc.