Additional investigations fail to alter the diagnosis of irritable bowel syndrome in subjects fulfilling the Rome Criteria

Citation
Lr. Hamm et al., Additional investigations fail to alter the diagnosis of irritable bowel syndrome in subjects fulfilling the Rome Criteria, AM J GASTRO, 94(5), 1999, pp. 1279-1282
Citations number
22
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
AMERICAN JOURNAL OF GASTROENTEROLOGY
ISSN journal
00029270 → ACNP
Volume
94
Issue
5
Year of publication
1999
Pages
1279 - 1282
Database
ISI
SICI code
0002-9270(199905)94:5<1279:AIFTAT>2.0.ZU;2-M
Abstract
OBJECTIVE: Irritable bowel syndrome (IBS) is diagnosed by the presence of a constellation of symptoms fulfilling the Manning or Pome Criteria, after e xclusion of organic disease. To exclude other diagnoses that might contribu te to the abdominal pain or bowel symptoms experienced by subjects with IBS , numerous screening algorithms have been advocated, incorporating lactose hydrogen breath tests, thyroid function tests, fecal ova and parasite deter mination, and colonic endoscopy/radiography. The utility of these tests in uncovering alternative diagnoses, other than IBS, was examined in 1452 pati ents. METHODS: Data were combined from two large multinational studies of IBS pat ients. All patients exhibited symptoms meeting the Pome criteria for IBS fo r at least 6 months before study entry. If prior evaluation had been >2 yr previously, patients underwent colonic endoscopy/radiography at study entry . In addition, thyroid function tests, fecal ova and parasite determination , and a lactose hydrogen breath test were performed. RESULTS: Lactose malabsorption was diagnosed in 23% (256/1122) of patients. Colonic abnormalities were detected in 2% (7/306) of patients; in four pat ients, colonic inflammation (n = 3) or obstruction (n = 1) may have contrib uted to symptoms of abdominal pain or altered bowel habits. Abnormal thyroi d-stimulating hormone levels were detected in 6% (67/1209) of patients, of whom half were hypothyroid and half were hyperthyroid. Positive fecal ova a nd parasite tests were noted in 2% (19/1154) of patients. CONCLUSIONS: Examination of screening tests in 1452 patients with an establ ished history of IBS revealed an incidence of lactose malabsorption compara ble to that in the general U.S. population and a low incidence of thyroid d ysfunction, ova and parasite infestation, or colonic pathology. The limited detection rates, added costs, and inconvenience of these tests suggest tha t their routine use in the diagnostic evaluation of established IBS patient s should be scrutinized. (C) 1999 by Am. Cell. of Gastroenterology.