Acantholytic variant of squamous cell carcinoma of the breast: A case report

Primary squamous cell carcinoma of the breast is a rare clinical entity. Tw o large review series found only five cases out of a total of 8351 breast m alignancies. This case report presents a patient with metaplastic, pseudoan giosarcomatous carcinoma or acantholytic variant of a squamous cell carcino ma of the breast. This diagnosis was based on the histological finding of h ighly atypical, acantholytic squamous cells. Because the tumor stained posi tive for keratin and negative for factor VIII, the diagnosis of angiosarcom a was ruled out. Although only scattered case reports have been published o n this histological variant, these tumors tend to follow an aggressive cour se.