N-acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity

Authors
Wakabayashi, H Matsumoto, H Hashimoto, K Teraguchi, S Takase, M Hayasawa, H
Citation
H. Wakabayashi et al., N-acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity, ANTIM AG CH, 43(5), 1999, pp. 1267-1269
Citations number
15
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
5
Year of publication
1999
Pages
1267 - 1269
Database
ISI
SICI code
0066-4804(199905)43:5<1267:NADEDO>2.0.ZU;2-S
Abstract
N-acylated or D enantiomer peptide derivatives based on the sequence RRWQWR MKK in lactoferricin B demonstrated antimicrobial activities greater than t hose of lactoferricin B against bacteria and fungi. The most potent peptide , conjugated with an Ii-carbon-chain acyl group, showed two to eight times lower MIC than lactoferricin B.