In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs

Authors
Akova, M Gur, D Livermore, DM Kocagoz, T Akalin, HE
Citation
M. Akova et al., In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs, ANTIM AG CH, 43(5), 1999, pp. 1298-1300
Citations number
13
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
5
Year of publication
1999
Pages
1298 - 1300
Database
ISI
SICI code
0066-4804(199905)43:5<1298:IVAOAA>2.0.ZU;2-F
Abstract
Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not a t pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy tha n established streptomycin-doxcycline and rifampin-doxycycline combinations .