Synergistic in vitro antimalarial activity of omeprazole and quinine

Authors
Skinner-Adams, T Davis, TME
Citation
T. Skinner-adams et Tme. Davis, Synergistic in vitro antimalarial activity of omeprazole and quinine, ANTIM AG CH, 43(5), 1999, pp. 1304-1306
Citations number
23
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
5
Year of publication
1999
Pages
1304 - 1306
Database
ISI
SICI code
0066-4804(199905)43:5<1304:SIVAAO>2.0.ZU;2-G
Abstract
Previous studies have shown that the proton pump inhibitor omeprazole has a ntimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine com binations were synergistic; however, chloroquine and omeprazole combination s were antagonistic. Artemisinin drugs had additive antimalarial activities with omeprazole.