Hymenoptera venom allergy in children.

Incidence of hymenoptera venom allergy in children is about 0.4 to 0.8%. Cl inical features usually range from urticaria to anaphylaxis. Fatal reaction s can occur brit with less frequency than in adults. Allergologic investiga tions must be performed in children with systemic or generalized reactions after hymenoptera stings, which may lend to venom immunotherapy. Venom immu notherapy is well reported but protocols differ according to the authors: u ltra-rush in 3 h, accelerated in 3 to 5 days and semi-rush in 2 to 8 weeks. Results are always excellent (90 to 100%). We report our experience with 9 1 children receiving venom immunotherapy. Clinical history and positivity o f skin tests indicated immunotherapy. Clinical symptoms were anaphylaxis (1 5.3%), serious reaction (37.3%) strong reaction (34%), and mild reaction (7 .6%). Changes in immunological parameters revealed wide individual variatio ns not differing from data in the literature, with no correlation with evol ution of immunotherapy. Venom immunotherapy appeared with good tolerability in children, whatever the protocol used. (C) 1999 Elsevier, Paris.