We discuss the time evolution of dust-to-gas mass ratio in the context of m
ulti-phase model of interstellar medium. Phase transition of interstellar g
as is considered to occur on a timescale of similar to 10(7-8) yr, accordin
g to a nonlinear open system model of interstellar medium. Since the phase
transition changes the dust formation and destruction rates, the dust-to-ga
s ratio also fluctuates on the same timescale. This explains the scatter of
the dust-to-gas ratios of spiral galaxies quantitatively, though we should
note the large observational uncertainty.