An NMR study of the structural basis of the wide range of pharmacological functions of acetylsalicylic acid

The interaction between acetylsalicylic acid (aspirin) and membrane was stu died NMR spectra. (1) NMR spectra showed acetylsalicylic acid did not inser t into membrane; (2) NMR spectrum recorded by spin-echo pulse sequence show ed protons of the aromatic ring interacted with membrane; (3) the change of spin-lattice relaxation (T-1) of P-31 was ascribed to the association of a cetylsalicylic acid to the polar head of lecithin; (4) the self-diffusion c oefficient measured by pulsed field gradients NMR showed the mobility of ac etylsalicylic acid was restricted by membrane and that acetylsalicylic acid changed membrane viscosity. Based on the results, the relationship between the interaction and the mechanism of the wide pharmacological functions of acetylsalicylic acid is discussed.