Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II

Authors
Tatsu, Y Shigeri, Y Ishida, A Kameshita, I Fujisawa, H Yumoto, N
Citation
Y. Tatsu et al., Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II, BIOORG MED, 9(8), 1999, pp. 1093-1096
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
1093 - 1096
Database
ISI
SICI code
0960-894X(19990419)9:8<1093:SOCPUC>2.0.ZU;2-R
Abstract
N-alpha-Fmoc-N-epsilon-(2-nitrobenzyloxycarbonyl)-lysine has been prepared and used in the solid-phase synthesis of caged peptides. The synthesized ca ged AIP (cagedKcagedKALRRQEAVDAL) showed characteristics required for caged peptides including a significantly reduced inhibitory activity to calmodul in-dependent protein kinase II and instantaneous recovery of the activity w ith photo-irradiation. (C) 1999 Elsevier Science Ltd. All rights reserved.