New synthetic heparin mimetics able to inhibit thrombin and factor Xa

Authors
Petitou, M Duchaussoy, P Driguez, PA Herault, JP Lormeau, JC Herbert, JM
Citation
M. Petitou et al., New synthetic heparin mimetics able to inhibit thrombin and factor Xa, BIOORG MED, 9(8), 1999, pp. 1155-1160
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
1155 - 1160
Database
ISI
SICI code
0960-894X(19990419)9:8<1155:NSHMAT>2.0.ZU;2-2
Abstract
Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an ant ithrombin III (AT III) binding pentasaccharide prolonged at the non-reducin g end by a thrombin binding domain have been obtained. The pentadecasacchar ide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than st andard heparin. (C) 1999 Published by Elsevier Science Ltd. All rights rese rved.