Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics

Authors
Petitou, M Driguez, PA Duchaussoy, P
Citation
M. Petitou et al., Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics, BIOORG MED, 9(8), 1999, pp. 1161-1166
Citations number
30
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
1161 - 1166
Database
ISI
SICI code
0960-894X(19990419)9:8<1161:SOHVFD>2.0.ZU;2-Q
Abstract
A synthetic heptadecasaccharide, comprising an antithrombin III binding dom ain, a thrombin binding domain, and a neutral methylated hexasaccharide seq uence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a p rotein released by activated platelets. (C) 1999 Published by Elsevier Scie nce Ltd. All rights reserved.