Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases

Authors
Kurihara, S Tsumuraya, T Fujii, I
Citation
S. Kurihara et al., Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases, BIOORG MED, 9(8), 1999, pp. 1179-1184
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
1179 - 1184
Database
ISI
SICI code
0960-894X(19990419)9:8<1179:SDODAA>2.0.ZU;2-Z
Abstract
:Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an in hibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for t heir ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR. (C) 1999 Elsevier Science Ltd. All rights reserved.