Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

Authors
Beck, JP Curry, MA Chorvat, RJ Fitzgerald, LW Gilligan, PJ Zaczek, R Trainor, GL
Citation
Jp. Beck et al., Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists, BIOORG MED, 9(8), 1999, pp. 1185-1188
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
1185 - 1188
Database
ISI
SICI code
0960-894X(19990419)9:8<1185:TTA-AC>2.0.ZU;2-0
Abstract
A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and di scovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants. (C ) 1999 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. A ll rights reserved.