Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa

Authors
Fevig, JM Buriak, J Stouten, PFW Knabb, RM Lam, GN Wong, PC Wexler, RR
Citation
Jm. Fevig et al., Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa, BIOORG MED, 9(8), 1999, pp. 1195-1200
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
1195 - 1200
Database
ISI
SICI code
0960-894X(19990419)9:8<1195:POPAIB>2.0.ZU;2-0
Abstract
The serine protease factor Xa is a critical enzyme in the blood coagulation cascade. Recently, the inhibition of factor Xa has begun to emerge as an a ttractive strategy for the discovery of novel antithrombotic agents. Here w e describe pyrrolidine and isoxazolidine benzamidines as novel and potent i nhibitors of factor Xa. (C) 1999 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.