E. Raposio et Pl. Santi, Topical application of DMSO as an adjunct to tissue expansion for breast reconstruction, BR J PL SUR, 52(3), 1999, pp. 194-197
The aim of this study was to evaluate the effectiveness of topical 60% dime
thyl sulphoxide (DMSO) prior to tissue expansion for breast reconstruction
in reducing expander pressure and length of treatment. Forty patients under
going immediate breast reconstruction with tissue expanders following modif
ied radical mastectomy were consecutively divided into two groups of 20 sub
jects each: group A (control) and group B (experimental). Patients from gro
up A underwent traditional tissue expansion, while, to patients of group B,
before each filling session, topical 60% DMSO was applied to the skin over
lying the expander by soaking-wet surgical sponges left in place for 30 min
. The average inflated volume was 395 cc (range 250-580 cc) in group A, and
410 cc (range 240-620 cc) in group B; no statistically significant differe
nce was found between these values. A statistically significant difference
was found between the expansion time of group A (mean 6 sessions; range 4-1
0 sessions with one filling session per week) and group B (mean 4 sessions;
range 2-6 sessions with one filling session per week). A statistically sig
nificant difference was also found between the average inflated volume per
session of group A (90 cc; range 60-130 cc) and group B (120 cc; range 90-1
60 cc). According to the data obtained by tonometry, a statistically signif
icant difference was found between the average pre-filling and post-filling
pressures of group A (28.4 and 66.5 mmHg, respectively) and group B (22.1
and 64.3 mmHg, respectively). Clinical benefits of pre-filling topical appl
ications of 60% DMSO observed in our trial were an enhancement of the total
volume inflatable per session and a significant shortening of the total ex
pansion period.