Kinetics of the interaction of myelin basic protein with phospholipid layers

The time dependence of the adsorption of myelin basic protein onto dipalmit oyl phosphatidyl glycerol multilayers has been followed directly, using a n ovel application of a microgravimetric gauge. Our results, supplemented by other data obtained by FTIR, show the ease and versatility of the quartz mi crobalance for investigating the interaction processes between proteins and phospholipid layers and show that the protein adsorption is accompanied by structural changes in the proteolipid ensemble and adsorbed liquid water; it is furthermore dependent on the mesoscopic defect morphology of the ense mble. (C) 1999 Elsevier Science B.V. All rights reserved.