Re. Mclendon et al., MALIGNANT SUPRATENTORIAL GLIAL-NEURONAL NEOPLASMS - REPORT OF 2 CASESAND REVIEW OF THE LITERATURE, Archives of pathology and laboratory medicine, 121(5), 1997, pp. 485-492
Citations number
45
Categorie Soggetti
Pathology,"Medical Laboratory Technology","Medicine, Research & Experimental
Objective.-Malignant neoplasms exhibiting mixed populations of neurona
l and glial cells occurring in the cerebral hemispheres of young adult
s and children are well recognized, but rare. A confusing array of dia
gnostic terms has arisen. We describe two patients with such tumors an
d review the literature concerning these interesting cases. Patients.-
A 21-year-old man and a 5-year-old girl presented with large, cystic,
intracerebral lesions on magnetic resonance images, which proved to be
composite neoplasms exhibiting malignant neurons and astrocytes. Resu
lts.-The 21-year-old man had a frontal lobe mass with enhancing and no
nenhancing regions, which corresponded to cerebral neuroblastoma and a
naplastic astrocytoma, respectively. The presence of occasional microt
ubules and rare primitive presynaptic processes, accompanied by antisy
naptophysin immunoreactivity, established the neuronal nature of the c
ells in the enhancing region. The nonenhancing region was composed of
a moderately cellular neoplasm of fibrillar astrocytes that were mitot
ically active. The 5-year-old girl presented with a left parietal lobe
neoplasm, which histologically was composed of lobular proliferations
of neuroblasts and glia. The neuroblastic populations exhibited evide
nce of maturation with small anaplastic cells, spindle-shaped cells, a
nd large dysmorphic ganglion cells. The glial tumor showed both well-d
ifferentiated fibrillary astrocytes with microcysts and anaplastic pop
ulations with central necrosis and pseudopalisading. Conclusions.-Pres
ent classification systems devised to describe mixed neuronal and glia
l tumors do not adequately encompass the diversity of morphologies pre
sented by these two cases. We conclude that the terms cerebral neurobl
astoma-anaplastic astrocytoma for case 1 and cerebral ganglioneuroblas
toma-glioblastoma for case 2 are preferred because they convey useful
clinical information by reflecting concepts already encompassed by the
World Health Organization's classification system of tumors of the ce
ntral nervous system.